Which of the following drugs can interact with montelukast?

Montelukast, a leukotriene receptor antagonist used primarily in the management of asthma and allergic rhinitis, can have interactions with certain herbal supplements and medications. St. John's wort, known for its use as a natural antidepressant, has the potential to induce the cytochrome P450 enzyme CYP3A4. Since montelukast is partially metabolized by this enzyme, the induction can lead to reduced effectiveness of the drug, as higher doses or alternative therapies may be required if its levels in the body decrease due to this interaction.

In contrast, paracetamol, ibuprofen, and amoxicillin do not share significant interactions with montelukast. Paracetamol and ibuprofen, both pain relievers, do not influence montelukast’s metabolic pathway notably. Similarly, amoxicillin, an antibiotic, does not present any known interference with the action or metabolism of montelukast. Understanding these interactions is essential for optimizing treatment plans and ensuring the efficacy of medications.